Jerwood, S. and Cohen, Jonathan (2008) Unexpected antimicrobial effect of statins. Journal of Antimicrobial Chemotherapy, 61 (2). pp. 362-364. ISSN 0305-7453

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Abstract

Objectives: Epidemiological studies of statins have suggested a link between statin therapy and a decreased risk of sepsis. It has been proposed that the mechanism underlying this apparent protective effect of statins relates to their known immunomodulatory and anti-inflammatory effects. The aim of this study was to explore the antimicrobial effect of statins.

Methods: Simvastatin (Merck) and fluvastatin (Novartis) were both tested against six of each of methicillin-susceptible and -resistant Staphylococcus aureus (MSSA + MRSA), and vancomycin-sensitive and -resistant enterococci (VSE + VRE) using a microtitre dilution method. The test was repeated five times for both statins against all 24 isolates. Vancomycin, linezolid and propranolol were used as controls, as appropriate.

Results and discussion: Simvastatin showed a significant antimicrobial effect against MSSA (mean MIC 29.2 mg/L) and to a lesser extent against MRSA (mean MIC 74.9 mg/L). Fluvastatin had a significantly less marked antimicrobial effect. Propranolol showed no antimicrobial effect. Simvastatin has a considerable antimicrobial effect in vitro and further testing of it is warranted.

Item Type:	Article
Schools and Departments:	Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects:	Q Science > QR Microbiology R Medicine > RC Internal medicine > RC0109 Infectious and parasitic diseases R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica
Depositing User:	Grecia GarciaGarcia
Date Deposited:	15 Aug 2011 11:03
Last Modified:	05 Oct 2017 18:27
URI:	http://sro.sussex.ac.uk/id/eprint/7210
Google Scholar:	28 Citations

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