University of Sussex
Browse

File(s) not publicly available

Pre-treatment waking cortisol response and vulnerability to interferon a induced depression

journal contribution
posted on 2023-06-07, 16:04 authored by Jessica EcclesJessica Eccles, Camille Lallemant, Farrah Mushtaq, Matthew Greenwood, Majella Keller, Bruno Golding, Jeremy Tibble, Inam Haq, Richard Whale
Depressive disorder is a common consequence of interferon a treatment. An understanding of the aetiological processes involved is evolving. HPA axis abnormalities are clearly described in community depressive disorder and represent vulnerability to depression development. We explored whether pre-treatment HPA axis abnormalities influence depression emergence during interferon a treatment. We examined waking HPA axis response via salivary cortisol sampling in 44 non-depressed, chronic hepatitis C infected patients due to commence standard interferon a treatment. Hamilton depression scales and the structured clinical interview for DSM-IV major depressive disorder status were administered monthly during treatment. Major depressive disorder developed in 26 of 44 subjects during interferon-a treatment. The pre-treatment waking cortisol response over 1h was significantly greater in the subsequent switch to depression group (F=4.23, p=0.046). The waking cortisol response pre-treatment with interferon a appears greater in those subsequently switching to depressive disorder during treatment. This waking response may join other vulnerability factors for depression emergence in this group. This model could prove a valuable tool in understanding non-iatrogenic depressive disorder in the general population and notably the role of cytokines.

History

Publication status

  • Published

Journal

European Neuropsychopharmacology

ISSN

0924-977X

Publisher

Elsevier

Issue

12

Volume

22

Page range

892-896

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-07-31

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC