Pre-treatment waking cortisol response and vulnerability to interferon α induced depression

Eccles, Jessica, Lallemant, Camille, Mushtaq, Farrah, Greenwood, Matthew, Keller, Majella, Golding, Bruno, Tibble, Jeremy, Haq, Inam and Whale, Richard (2012) Pre-treatment waking cortisol response and vulnerability to interferon α induced depression. European Neuropsychopharmacology, 22 (12). pp. 892-896. ISSN 0924-977X

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Depressive disorder is a common consequence of interferon α treatment. An understanding of the aetiological processes involved is evolving. HPA axis abnormalities are clearly described in community depressive disorder and represent vulnerability to depression development. We explored whether pre-treatment HPA axis abnormalities influence depression emergence during interferon α treatment. We examined waking HPA axis response via salivary cortisol sampling in 44 non-depressed, chronic hepatitis C infected patients due to commence standard interferon α treatment. Hamilton depression scales and the structured clinical interview for DSM-IV major depressive disorder status were administered monthly during treatment. Major depressive disorder developed in 26 of 44 subjects during interferon-α treatment. The pre-treatment waking cortisol response over 1h was significantly greater in the subsequent switch to depression group (F=4.23, p=0.046). The waking cortisol response pre-treatment with interferon α appears greater in those subsequently switching to depressive disorder during treatment. This waking response may join other vulnerability factors for depression emergence in this group. This model could prove a valuable tool in understanding non-iatrogenic depressive disorder in the general population and notably the role of cytokines.

Item Type: Article
Keywords: Depression; Aetiology; HPA axis; Interferon; Cytokines; Hepatitis C virus; Neuroendocrinology; Serotonin
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > RM Therapeutics. Pharmacology
Depositing User: Grecia GarciaGarcia
Date Deposited: 31 Jul 2012 09:28
Last Modified: 11 Nov 2019 15:58
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