University of Sussex
Browse

File(s) not publicly available

Deletion variant of alpha 2b-adrenergic receptor gene moderates the effect of COMT val(158)met polymorphism on episodic memory performance

journal contribution
posted on 2023-06-07, 16:03 authored by Ayana A. Gibbs, Kris H. Naudts, Ruben T. Azevedo, Anthony S. David
The COMT val(158) variant has been associated with impaired cognitive function compared to the Met(158) variant yet gene gene interactions are not well described. In this study we demonstrate an interaction between this COMT polymorphism and a deletion variant of ADRA2B, the gene encoding the alpha 2b-adrenergic receptor on episodic memory performance. Specifically, carriage of the ADRA2B deletion abolished the relative memory impairment in homozygous COMT val(158) carriers compared to Met(158) carriers.

History

Publication status

  • Published

Journal

European Neuropsychopharmacology

ISSN

0924-977X

Publisher

Elsevier

Issue

4

Volume

20

Page range

272-275

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2011-08-09

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC