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Deletion variant of alpha 2b-adrenergic receptor gene moderates the effect of COMT val(158)met polymorphism on episodic memory performance
journal contribution
posted on 2023-06-07, 16:03 authored by Ayana A. Gibbs, Kris H. Naudts, Ruben T. Azevedo, Anthony S. DavidThe COMT val(158) variant has been associated with impaired cognitive function compared to the Met(158) variant yet gene gene interactions are not well described. In this study we demonstrate an interaction between this COMT polymorphism and a deletion variant of ADRA2B, the gene encoding the alpha 2b-adrenergic receptor on episodic memory performance. Specifically, carriage of the ADRA2B deletion abolished the relative memory impairment in homozygous COMT val(158) carriers compared to Met(158) carriers.
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Publication status
- Published
Journal
European NeuropsychopharmacologyISSN
0924-977XPublisher
ElsevierExternal DOI
Issue
4Volume
20Page range
272-275Department affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2011-08-09Usage metrics
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