Mitochondrial DNA changes in pedunculopontine cholinergic neurons in Parkinson’s disease

Bury, Alexander G, Pyle, Angela, Elson, Joanna L, Greaves, Laura, Morris, Christopher M, Hudson, Gavin and Pienaar, Ilse (2017) Mitochondrial DNA changes in pedunculopontine cholinergic neurons in Parkinson’s disease. Annals of Neurology, 82 (6). pp. 1016-1021. ISSN 0364-5134

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Abstract

In Parkinson’s disease (PD), mitochondrial dysfunction associates with nigral dopaminergic neuronal loss. Cholinergic neuronal loss co-occurs, particularly within a brainstem structure, the pedunculopontine nucleus (PPN). We isolated single cholinergic neurons from post-mortem PPNs of aged controls and PD patients. Mitochondrial DNA (mtDNA) copy number and mtDNA deletions were increased significantly in PD patients compared to controls. Furthermore, compared to controls the PD patients had significantly more PPN cholinergic neurons containing mtDNA deletion levels exceeding 60%, a level associated with deleterious effects on oxidative phosphorylation. The current results differ from studies reporting mtDNA depletion in nigral dopaminergic neurons of PD patients.

Item Type: Article
Schools and Departments: School of Life Sciences > Neuroscience
Depositing User: Ilse Pienaar
Date Deposited: 27 Apr 2018 13:23
Last Modified: 02 Jul 2019 13:49
URI: http://sro.sussex.ac.uk/id/eprint/71565

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