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Gabapentin evoked changes in functional activity in nociceptive regions in the brain of the anaesthetized rat: an fMRI study

journal contribution
posted on 2023-06-07, 16:03 authored by Ricardo Governo, P G Morris, C A Marsden, V Chapman
Random effect analysis revealed that the lower dose of GBP produced significant (P<0.001) increases in BOLD signal intensity in several brain regions, including the thalamus and periaqueductal grey (PAG), compared to basal. This dose of GBP also produced significant (P<0.001) decreases in BOLD signal intensity in the amygdala and the entorhinal cortex. Increasing the dose of GBP (100 mg kg(-1)) produced significantly greater changes in BOLD signal intensity in several brain regions including the thalamus and PAG. MAP was not significantly altered by GBP, compared to saline.Conclusions and implications: GBP had marked positive and negative effects on BOLD signal intensity in a number of brain regions in naïve rats. The activation of key areas involved in nociceptive processing indicate a supraspinal site of action of GBP and this may contribute to its well-described analgesic effects in animal models of pain and clinical studies.

History

Publication status

  • Published

Journal

British Journal of Pharmacology

ISSN

0007-1188

Publisher

Wiley-Blackwell

Issue

7

Volume

153

Page range

1558-1567

Department affiliated with

  • Clinical and Experimental Medicine Publications

Notes

IDS Number: 282HY

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2011-08-24