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Abstract

Random effect analysis revealed that the lower dose of GBP produced significant (P<0.001) increases in BOLD signal intensity in several brain regions, including the thalamus and periaqueductal grey (PAG), compared to basal. This dose of GBP also produced significant (P<0.001) decreases in BOLD signal intensity in the amygdala and the entorhinal cortex. Increasing the dose of GBP (100 mg kg(-1)) produced significantly greater changes in BOLD signal intensity in several brain regions including the thalamus and PAG. MAP was not significantly altered by GBP, compared to saline.Conclusions and implications: GBP had marked positive and negative effects on BOLD signal intensity in a number of brain regions in naïve rats. The activation of key areas involved in nociceptive processing indicate a supraspinal site of action of GBP and this may contribute to its well-described analgesic effects in animal models of pain and clinical studies.

Item Type:	Article
Additional Information:	IDS Number: 282HY
Keywords:	CHANNEL ALPHA(2)DELTA SUBUNITS; RANDOMIZED CONTROLLED-TRIAL; GAMMA-AMINOBUTYRIC-ACID; NEUROPATHIC PAIN MODEL; CALCIUM-CHANNEL; PERIAQUEDUCTAL GRAY; DORSAL-HORN; POSTHERPETIC NEURALGIA; INTRATHECAL GABAPENTIN; CENTRAL SENSITIZATION
Schools and Departments:	Brighton and Sussex Medical School > Clinical and Experimental Medicine Brighton and Sussex Medical School > Division of Medical Education
Subjects:	R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology
Depositing User:	Tracey O'Gorman
Date Deposited:	24 Aug 2011 15:03
Last Modified:	22 Sep 2017 11:51
URI:	http://sro.sussex.ac.uk/id/eprint/7156
Google Scholar:	8 Citations

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