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Ways and means of eukaryotic mRNA decay
journal contribution
posted on 2023-06-09, 08:54 authored by Vidya Balagopal, Lydia Fluch, Tracy NissanMessenger RNA degradation is an important point of control for gene expression. Genome-wide studies on mRNA stability have demonstrated its importance in adaptation and stress response. Most of the key players in mRNA decay appear to have been identified. The study of these proteins brings insight into the mechanism of general and specific targeting of transcripts for degradation. Recruitment and assembly of mRNP complexes enhance and bring specificity to mRNA decay. mRNP complexes can form larger structures that have been found to be ubiquitous in nature. Discovery of P-Bodies, an archetype of this sort of aggregates, has generated interest in the question of where mRNA degrades. This is currently an open question under extensive investigation. This review will discuss in detail the recent developments in the regulation of mRNA decay focusing on yeast as a model system. This article is part of a Special Issue entitled: Nuclear Transport and RNA Processing.
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Publication status
- Published
File Version
- Accepted version
Journal
BBA - Biochimica et Biophysica ActaPublisher
ElsevierExternal DOI
Issue
6Volume
1819Page range
593-603Department affiliated with
- Biochemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-11-17First Open Access (FOA) Date
2017-11-17First Compliant Deposit (FCD) Date
2017-11-17Usage metrics
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