University of Sussex
Browse

File(s) not publicly available

A model for chromosome condensation based on the interplay between condensin and topoisomerase II

journal contribution
posted on 2023-06-20, 14:16 authored by Jon BaxterJon Baxter
The compaction of chromatin that occurs when cells enter mitosis is probably the most iconic process of dividing cells. Mitotic chromosomal compaction or ‘condensation’ is functionally linked to resolution of chromosomal intertwines, transcriptional shut-off and complete segregation of chromosomes. At present, understanding of the molecular events required to convert interphase chromatin into mitotic chromosomes is limited. Here, we review recent advances in the field, focusing on potential chromosomal compaction mechanisms and their importance to chromosome segregation. We propose a model of how metaphase chromosomes could be shaped based on the enzymatic activities of condensin and topoisomerase II in overwinding and relaxation of the DNA fiber during mitosis. We suggest that condensin overwinding is an important requirement for intertwine resolution by topoisomerase II and, together with the inhibition of transcription, contributes to cytological mitotic chromosome appearance or ‘condensation’

Funding

Understanding the mechanisms of termination of DNA replication in eukaryotes Fellow: Baxter; G0222; ROYAL SOCIETY; UO090655

History

Publication status

  • Published

Journal

Trends in Genetics

ISSN

0168-9525

Publisher

Elsevier

Issue

3

Volume

28

Page range

110-117

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Research groups affiliated with

  • Genome Damage and Stability Centre Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2017-11-15

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC