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Human hippocampal theta power indicates movement onset and distance travelled

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posted on 2023-06-09, 08:37 authored by Daniel Bush, James A Bisby, Chris BirdChris Bird, Stephanie Gollwitzer, Roman Rodionov, Beate Diehl, Andrew W McEvoy, Matthew C Walker, Neil Burgess
Theta frequency oscillations in the 6- to 10-Hz range dominate the rodent hippocampal local field potential during translational movement, suggesting that theta encodes self-motion. Increases in theta power have also been identified in the human hippocampus during both real and virtual movement but appear as transient bursts in distinct high- and low-frequency bands, and it is not yet clear how these bursts relate to the sustained oscillation observed in rodents. Here, we examine depth electrode recordings from the temporal lobe of 13 presurgical epilepsy patients performing a selfpaced spatial memory task in a virtual environment. In contrast to previous studies, we focus on movement-onset periods that incorporate both initial acceleration and an immediately preceding stationary interval associated with prominent theta oscillations in the rodent hippocampal formation. We demonstrate that movementonset periods are associated with a significant increase in both low (2–5 Hz)- and high (6–9 Hz)-frequency theta power in the human hippocampus. Similar increases in low- and high-frequency theta power are seen across lateral temporal lobe recording sites and persist throughout the remainder of movement in both regions. In addition, we show that movement-related theta power is greater both before and during longer paths, directly implicating human hippocampal theta in the encoding of translational movement. These findings strengthen the connection between studies of theta-band activity in rodents and humans and offer additional insight into the neural mechanisms of spatial navigation.

History

Publication status

  • Published

File Version

  • Published version

Journal

Proceedings of the National Academy of Sciences

ISSN

1091-6490

Publisher

National Academy of Sciences

Issue

46

Volume

114

Page range

12297-12302

Department affiliated with

  • Psychology Publications

Research groups affiliated with

  • Sussex Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-11-03

First Open Access (FOA) Date

2017-11-03

First Compliant Deposit (FCD) Date

2017-11-03

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