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Generation of multi-innervated dendritic spines as a novel mechanism of long-term memory formation
journal contribution
posted on 2023-06-09, 08:24 authored by Karl Peter Giese, Wajeeha AzizWajeeha Aziz, Igor Kraev, Michael G StewartNMDA receptor-dependent long-term potentiation (LTP) at hippocampal CA1 synapses is a well-accepted mechanism underlying long-term memory (LTM) formation. However, studies with mice that lack threonine-286 autophosphorylation of aCaMKII have shown that hippocampal LTM can be formed despite absence of NMDA receptor-dependent CA1 LTP. After multiple training trials, LTM formation in these mutants is linked to the generation of multi-innervated dendritic spines (MIS), a spine that receives typically two presynaptic inputs. PSD-95 overexpression is sufficient for MIS generation and depends on mTOR signaling. LTM that involves MIS generation appears less modifiable upon retrieval in comparison to LTM without MIS generation. Taken together, MIS generation appears to be a novel LTM mechanism after multiple training trials, which may occur in diseases with impaired LTP or conditions affecting negative feedback CaMKII signaling at the synapse.
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Publication status
- Published
File Version
- Published version
Journal
Neurobiology of learning and memoryISSN
1095-9564Publisher
ElsevierExternal DOI
Volume
124Page range
48-51Department affiliated with
- BSMS Neuroscience Publications
Research groups affiliated with
- Sussex Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-10-23First Open Access (FOA) Date
2017-10-23First Compliant Deposit (FCD) Date
2017-10-23Usage metrics
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