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Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum

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posted on 2023-06-07, 15:58 authored by Simon WaddellSimon Waddell, Natalie J Garton, Anna L Sherratt, Su-Min Lee, Rebecca J Smith, Claire Senner, Jason Hinds, Kumar Rajakumar, Richard A Adegbola, Gurdyal S Besra, Philip D Butcher, Michael R Barer
As nonreplicating tubercle bacilli are tolerant to the cidal action of antibiotics and resistant to multiple stresses, identification of this persister-like population of tubercle bacilli in sputum presents exciting and tractable new opportunities to investigate both responses to chemotherapy and the transmission of tuberculosis.

History

Publication status

  • Published

File Version

  • Published version

Journal

PLoS Medicine

ISSN

1549-1676

Publisher

Public Library of Science

External DOI

Issue

4

Volume

5

Page range

634-645

Department affiliated with

  • Clinical and Experimental Medicine Publications

Notes

IDS Number: 293XX Article Number: e75

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2011-08-19

First Open Access (FOA) Date

2016-03-22

First Compliant Deposit (FCD) Date

2016-08-17

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    University of Sussex (Publications)

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    Keywords

    MycobacteriumInfectionTranscriptional profilingTuberculosisHost-pathogen interactions

    Licence

    CC BY 4.0

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