Waddell, Simon, Garton, Natalie J, Sherratt, Anna L, Lee, Su-Min, Smith, Rebecca J, Senner, Claire, Hinds, Jason, Rajakumar, Kumar, Adegbola, Richard A, Besra, Gurdyal S, Butcher, Philip D and Barer, Michael R (2008) Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum. PLoS Medicine, 5 (4). pp. 634-645. ISSN 1549-1676

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Abstract

As nonreplicating tubercle bacilli are tolerant to the cidal action of antibiotics and resistant to multiple stresses, identification of this persister-like population of tubercle bacilli in sputum presents exciting and tractable new opportunities to investigate both responses to chemotherapy and the transmission of tuberculosis.

Item Type:	Article
Additional Information:	IDS Number: 293XX Article Number: e75
Keywords:	Mycobacterium Infection Transcriptional profiling Tuberculosis Host-pathogen interactions
Schools and Departments:	Brighton and Sussex Medical School > Clinical and Experimental Medicine Brighton and Sussex Medical School > Global Health and Infection
Subjects:	Q Science > QR Microbiology > QR0075 Bacteria Q Science > QR Microbiology > QR0180 Immunology R Medicine > RC Internal medicine
Depositing User:	Simon Waddell
Date Deposited:	19 Aug 2011 15:02
Last Modified:	02 Jul 2019 18:04
URI:	http://sro.sussex.ac.uk/id/eprint/7061
Google Scholar:	90 Citations

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