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Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety
journal contribution
posted on 2023-06-09, 08:06 authored by Supojjanee Sansook, Cory A Ocasio, Iain Day, Graham J Tizzard, Simon Coles, Oleg Fedorov, James Bennett, Jon Elkins, John SpencerJohn SpencerA series of 3-methylidene-1H-indol-2(3H)-ones substituted with a 5- or 6- pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation reaction of SF5-substituted oxindoles with a range of aldehydes. The resulting products were characterized by x-ray crystallography studies and were tested for biological activity versus a panel of cell lines and protein kinases. Some exhibited single digit nM activity.
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- Published
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- Published version
Journal
Organic and Biomolecular ChemistryISSN
1477-0520Publisher
Royal Society of ChemistryExternal DOI
Issue
15Volume
40Page range
8655-8660Department affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-10-06First Open Access (FOA) Date
2017-11-22First Compliant Deposit (FCD) Date
2017-09-30Usage metrics
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