Sansook, Supojjanee, Ocasio, Cory A, Day, Iain J, Tizzard, Graham J, Coles, Simon, Fedorov, Oleg, Bennett, James, Elkins, Jon and Spencer, John (2017) Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety. Organic and Biomolecular Chemistry, 40 (15). pp. 8655-8660. ISSN 1477-0520
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Abstract
A series of 3-methylidene-1H-indol-2(3H)-ones substituted with a 5- or 6- pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation reaction of SF5-substituted oxindoles with a range of aldehydes. The resulting products were characterized by x-ray crystallography studies and were tested for biological activity versus a panel of cell lines and protein kinases. Some exhibited single digit nM activity.
Item Type: | Article |
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Schools and Departments: | School of Life Sciences > Chemistry |
Subjects: | Q Science > QD Chemistry > QD0241 Organic chemistry Q Science > QD Chemistry > QD0241 Organic chemistry > QD0411 Organometallic chemistry and compounds Q Science > QD Chemistry > QD0901 Crystallography |
Depositing User: | John Spencer |
Date Deposited: | 06 Oct 2017 08:16 |
Last Modified: | 02 Jul 2019 17:21 |
URI: | http://sro.sussex.ac.uk/id/eprint/70385 |
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