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Bozzali, Marco, Giulietti, Giovanni, Basile, Barbara, Serra, Laura, Spanò, Barbara, Perri, Roberta, Giubilei, Franco, Marra, Camillo, Caltagirone, Carlo and Cercignani, Mara (2012) Damage to the cingulum contributes to alzheimer's disease pathophysiology by deafferentation mechanism. Human Brain Mapping, 33 (6). pp. 1295-1308. ISSN 1065-9471
Full text not available from this repository.Abstract
This study investigates the differential contribution of gray matter (GM) atrophy and deafferentation through white matter (WM) damage in the clinical progression of Alzheimer's disease (AD). Thirty-one patients with probable AD, 23 with amnestic mild cognitive impairment (a-MCI), and 14 healthy subjects underwent MRI scanning at 3T. Voxel-based morphometry was used to assess regional GM atrophy in AD and a-MCI patients. Diffusion tensor-MRI tractography was used to reconstruct the cingulum bilaterally, and to quantify, voxel-by-voxel, its fractional anisotropy (FA) and mean diffusivity (MD) (measures of microscopic WM integrity). Atrophy of the cinguli was also assessed by means of jacobian determinants (JD) of local transformations. In AD patients, four clusters of reduced GM were found nearby the cinguli, in the posterior (PCC) and anterior cingulate cortex, and in the hippocampal/parahippocampal areas. Widespread areas of reduced FA and increased MD were found in the cinguli of both, AD and a-MCI patients. A region of macroscopic atrophy was detectable in AD patients only. Strong associations were found between local GM densities in the four identified clusters, and measures of micro- and (to a lesser extent) macroscopic damage of patients' cinguli. Linear regression analyses revealed that MD in the cinguli predicts patients' measures of episodic memory in combination with GM density of hippocampal/parahippocampal areas, and measures of global cognition in combination with GM density of the PCC. This study indicates that brain deafferentation though the cingulum is likely to play a remarkable role in progressive development of cognitive impairment in AD. Hum Brain Mapp, 2011. © 2011 Wiley-Liss, Inc.
| Item Type: | Article |
|---|---|
| Keywords: | AD;MCI;deafferentation;VBM;tractography;DT-MRI;cingulum |
| Schools and Departments: | Brighton and Sussex Medical School > Clinical and Experimental Medicine Brighton and Sussex Medical School > Neuroscience |
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders |
| Depositing User: | Mara Cercignani |
| Date Deposited: | 25 Jan 2013 09:56 |
| Last Modified: | 26 Sep 2017 13:11 |
| URI: | http://sro.sussex.ac.uk/id/eprint/7034 |