Cardiovascular drug therapy for human newborn: review of pharmacodynamic data

Ergenekon, E, Rojas-Anaya, H, Bravo, MC, Kotidis, C, Mahoney, Liam and Rabe, Heike (2018) Cardiovascular drug therapy for human newborn: review of pharmacodynamic data. Current Pharmaceutical Design, 23 (38). pp. 5850-5860. ISSN 1873-4286

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Circulatory failure in preterm and term newborn infants is commonly treated with inotropes or vasoactive medications. In this structured literature review, the available data on pharmacodynamic effects of the inotropes adrenaline, dobutamine, dopamine, levosimendan, milrinone, noradrenaline, and the vasoactive drugs vasopressin and hydrocortisone are presented.


Structured searches were conducted to identify relevant articles according to pre-defined inclusion criteria which were human clinical trials published after 2000.


Out of 101 identified eligible studies only 22 studies met the criteria for evidence based practice guidelines level I to IV. The most prevalent pharmacodynamic effects were increase in blood pressure and/or heart rate, which were also the most frequently studied circulatory parameters.


This review demonstrates the need for further systematic studies on all reviewed drugs with incorporation of novel non-invasive biomarkers in this vulnerable patient group, for more timely and appropriate treatment for clinical efficacy.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects: R Medicine > RJ Pediatrics > RJ0251 Newborn infants Including physiology, care, treatment, diseases
Depositing User: Judy Keogh
Date Deposited: 25 Sep 2017 14:05
Last Modified: 19 Jul 2019 13:31

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