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Asymmetry of parietal interhemispheric connections in humans

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posted on 2023-06-07, 15:58 authored by Giacomo Koch, Mara Cercignani, Sonia Bonnì, Viola Giacobbe, Giulia Bucchi, Viviana Versace, Carlo Caltagirone, Marco Bozzali
Visuospatial abilities are preferentially mediated by the right hemisphere. Although this asymmetry of function is thought to be due to an unbalanced interaction between cerebral hemispheres, the underlying neurophysiological substrate is still largely unknown. Here, using a method of trifocal transcranial magnetic stimulation, we show that the right, but not left, human posterior parietal cortex exerts a strong inhibitory activity over the contralateral homologous area by a short-latency connection. We also clarify, using diffusion-tensor magnetic resonance imaging, that such an interaction is mediated by direct transcallosal projections located in the posterior corpus callosum. We argue that this anatomo-functional network may represent a possible neurophysiological basis for the ongoing functional asymmetry between parietal cortices, and that its damage could contribute to the clinical manifestations of neglect.

History

Publication status

  • Published

File Version

  • Published version

Journal

Journal of Neuroscience

ISSN

1529-2401

Publisher

Society for Neuroscience

Issue

24

Volume

31

Page range

8967-8975

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2011-08-17

First Open Access (FOA) Date

2016-03-22

First Compliant Deposit (FCD) Date

2016-11-17

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