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Chromatin reorganisation in Epstein-Barr virus-infected cells and its role in cancer development

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journal contribution
posted on 2023-06-09, 07:53 authored by Michelle WestMichelle West
The oncogenic Epstein-Barr virus (EBV) growth transforms B cells and drives lymphoma and carcinoma development. The virus encodes four key transcription factors (EBNA2, EBNA3A, EBNA3B and EBNA3C) that hijack host cell factors to bind gene control elements and reprogramme infected B cells. These viral factors predominantly target long-range enhancers to alter the expression of host cell genes that control B cell growth and survival and facilitate virus persistence. Enhancer and superenhancer binding by these EBNAs results in large-scale reorganisation of three-dimensional enhancer–promoter architecture to drive the overexpression of oncogenes, the silencing of tumour suppressors and the modulation of transcription, cell-cycle progression, migration and adhesion.

Funding

How does Epstein-Barr virus contribute to the development of Burkitt's and other B-cell lymphomas?; G0902; LEUKAEMIA AND LYMPHOMA RESEARCH; 12035

Elucidating the regulation and function of the cell-cycle regulator RGC-32 in Epstein-Barr virus transformed cells; G1149; MRC-MEDICAL RESEARCH COUNCIL; MR/K01952X/\

Regulation and function of RUNX1 and RUNX3 in human B cells; G1197; LEUKAEMIA AND LYMPHOMA RESEARCH; 13032

Gene deregulation in lymphoma: uncovering mechanisms and pathways exploited by Epstein-Barr virus; G1700; LEUKAEMIA AND LYMPHOMA RESEARCH; 15024

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Current Opinion in Virology

ISSN

1879-6257

Publisher

Elsevier

Volume

26

Page range

149-155

Department affiliated with

  • Biochemistry Publications

Research groups affiliated with

  • Haematology Research Group Publications
  • Gene Expression Research Group Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-09-12

First Open Access (FOA) Date

2018-09-12

First Compliant Deposit (FCD) Date

2017-09-12

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