Optical force on diseased blood cells: towards the optical sorting of biological matter

Totero Gongora, Juan Sebastian and Fratalocchi, Andrea (2015) Optical force on diseased blood cells: towards the optical sorting of biological matter. Optics and Lasers in Engineering, 76. pp. 40-44. ISSN 0143-8166

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By employing a series of massively parallel ab-initio simulations, we study how optical forces act on biological matter subject to morphological disease. As a representative case study, we here consider the case of Plasmodium falciparum on red blood cells (RBC) illuminated by a monochromatic plane wave. Realistic parameters for the geometry and the refractive index are then taken from published experiments. In our theoretical campaign, we study the dependence of the optical force on the disease stage for different incident wavelengths. We show that optical forces change significantly with the disease, with amplitude variation in the hundreds of pN range. Our results open up new avenues for the design of new optical systems for the treatment of human disease.

Item Type: Article
Keywords: Optical forces, Finite-Difference Time-Domain, Diseased red-blood cells
Schools and Departments: School of Mathematical and Physical Sciences > Physics and Astronomy
Research Centres and Groups: Atomic, Molecular and Optical Physics Research Group
Subjects: Q Science > QC Physics > QC0350 Optics. Light
Q Science > QC Physics > QC0350 Optics. Light > QC0395 Physical optics
Q Science > QM Human anatomy > QM0550 Human and comparative histology
R Medicine > RC Internal medicine > RC0109 Infectious and parasitic diseases
Depositing User: Juan Sebastian Totero Gongora
Date Deposited: 05 Jul 2018 12:33
Last Modified: 02 Jul 2019 15:15
URI: http://sro.sussex.ac.uk/id/eprint/69634

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