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Cardiovascular mitochondrial dysfunction induced by cocaine: biomarkers and possible beneficial effects of modulators of oxidative stress

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posted on 2023-06-09, 07:17 authored by Manuela Graziani, Paolo Sarti, Marzia Arese, Maria Chiara Magnifico, Aldo Badiani, Luciano Saso
Cocaine abuse has long been known to cause morbidity and mortality due to its cardiovascular toxic effects. The pathogenesis of the cardiovascular toxicity of cocaine use has been largely reviewed, and the most recent data indicate a fundamental role of oxidative stress in cocaine-induced cardiovascular toxicity, indicating that mitochondrial dysfunction is involved in the mechanisms of oxidative stress. The comprehension of the mechanisms involving mitochondrial dysfunction could help in selecting the most appropriate mitochondria injury biological marker, such as superoxide dismutase-2 activity and glutathionylated hemoglobin. The potential use of modulators of oxidative stress (mitoubiquinone, the short-chain quinone idebenone, and allopurinol) in the treatment of cocaine cardiotoxic effects is also suggested to promote further investigations on these potential mitochondria-targeted antioxidant strategies.

History

Publication status

  • Published

File Version

  • Published version

Journal

Oxidative Medicine and Cellular Longevity

ISSN

1942-0900

Publisher

Hindawi

Volume

2017

Article number

a3034245

Department affiliated with

  • Psychology Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-07-20

First Open Access (FOA) Date

2017-07-20

First Compliant Deposit (FCD) Date

2017-07-20

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