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Comprehensive geriatric assessment in men aged 70 years or older with localised prostate cancer undergoing radical radiotherapy

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posted on 2023-06-09, 06:27 authored by G E C Osborne, Sally Appleyard, D C Gilbert, Chris JonesChris Jones, M Villanueva, E Peasgood, A Robinson, A Nikapota, A Ring
Aims Treatment decisions for men aged 70 years or over with localised prostate cancer need to take into account the risk of death from competing causes and fitness for the proposed treatment. Objective assessments such as those included in a comprehensive geriatric assessment (CGA) might help to inform the decision-making process. The aim of this study was to describe the CGA scores of a cohort of older men with prostate cancer, evaluate potential screening tools in this population and assess whether any CGA component predicts significant acute radiotherapy toxicity. Materials and methods This was a prospective cohort study undertaking pretreatment CGA, Vulnerable Elders Survey (VES-13) and G8 assessment in patients aged 70 years and over with localised prostate cancer planned to undergo radical external beam radiotherapy. Results In total, 178 participants were recruited over a 3 year period and underwent a CGA. Fifty-five (30.1%) participants were defined as having health needs identified by their CGA. Both VES-13 and G8 screening tools showed a statistically significant association with CGA needs (P < 0.001 and X2 = 15.02, P < 0.001, respectively), but their sensitivity was disappointing. There was no association between a CGA (or its components) and significant acute radiotherapy toxicity. Conclusions Many older men with localised prostate cancer are vulnerable according to a CGA. The screening tools evaluated were not sufficiently sensitive to identify this group. CGA outcome does not predict for significant acute radiotherapy toxicity.

Funding

Prostate Cancer in Older Men Over Seventy (POCAMOS); G0975; SUSSEX CANCER FUND FOR TREATMENT AND RESEARCH

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Clinical Oncology

ISSN

0936-6555

Publisher

Elsevier

Issue

9

Volume

29

Page range

609-616

Department affiliated with

  • Primary Care and Public Health Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-06-20

First Open Access (FOA) Date

2018-06-05

First Compliant Deposit (FCD) Date

2017-05-31

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