Macedo et al_manuscript_final proof_27Apr2017.pdf (604.08 kB)
Is sleep disruption a risk factor for Alzheimer’s disease?
journal contribution
posted on 2023-06-09, 06:20 authored by Arthur Cassa Macedo, Sara Balouch, Naji TabetNaji TabetSleep disturbances are routinely encountered in Alzheimer’s disease (AD) and affect about 25–40% of patients in the mild-to-moderate stages of the disease. In many, sleep pathology may represent a symptom of the underlying neurodegeneration. However, a history of sleep disruption occurring years prior to onset of cognitive symptoms could represent a potential risk factor for AD. The aim of the present narrative review was to evaluate current evidence linking sleep disturbances with AD development and to understand the mechanisms that may contribute to this. Although the mechanisms by which poor sleep may contribute to AD genesis is not fully understood, emerging evidence linking disturbances in the sleep wake cycle with Aß deposition is shedding light on the relationship between sleep pathology and the subsequent development of AD. Aß burden appears to be enhanced by sleep-wake cycle disruptions and is suspected as being an important mechanism by which sleep disruptions contribute in AD development. Other mechanisms triggered by sleep disruption may also be involved in AD development, such as brain hypoxia, oxidative stress, circadian activity rhythms disturbances, overexpression of orexins, and blood-brain barrier impairment. Further understanding of the link between sleep disturbances and future development of AD is still needed before sleep disturbances are clearly marked as a preventable risk factor for AD. In these circumstances, early lifestyle interventions to help increase the quantity and quality of sleep may have a favorable outcome on decreasing the incidence of AD and this needs to be investigated further.
History
Publication status
- Published
File Version
- Accepted version
Journal
Journal of Alzheimer's DiseaseISSN
1387-2877Publisher
IOS PressExternal DOI
Issue
4Volume
58Page range
993-1002Department affiliated with
- BSMS Neuroscience Publications
Research groups affiliated with
- Analysis and Partial Differential Equations Research Group Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-05-19First Open Access (FOA) Date
2017-05-19First Compliant Deposit (FCD) Date
2017-05-19Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC