Ahmadizar, Fariba, Vijverberg, Susanne J H, Arets, Hubertus G M, de Boer, Anthonius, Turner, Steve, Devereux, Graham, Arabkhazaeli, Ali, Soares, Patricia, Mukhopadhyay, Somnath, Garssen, Johan and others, (2017) Early life antibiotic use and the risk of asthma and asthma exacerbations in children. Pediatric Allergy And Immunology, 28 (5). pp. 430-437. ISSN 0905-6157

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Abstract

Background: The use of antibiotic therapy early in life might influence the risk of developing asthma. Studies assessing the influence of early life antibiotic use on the risk of asthma exacerbations are limited, and the results are inconsistent. Therefore, the aim of this study was to assess the association between use of antibiotic during the first three years of life and the risk of developing childhood asthma and the occurrence of asthma exacerbations.

Methods: Data from four large childhood cohorts were used; two population-based cohorts to study the risk of developing asthma: Generation R (n=7,393, the Netherlands) and SEATON (n=891, Scotland, UK), and two asthma cohorts to assess the risk of asthma exacerbations: PACMAN (n=668, the Netherlands) and BREATHE (n=806, Scotland, UK). Odds ratios (ORs) were derived from logistic regression analysis within each database followed by pooling the results using a fixed- or random-effect model.

Results: Antibiotic use in early life was associated with an increased risk of asthma in a meta-analysis of the Generation R and SEATON data (OR: 2.18, 95% CI: 1.04-4.60; I2: 76.3%). There was no association between antibiotic use in early life and risk of asthma exacerbations later in life in a meta-analysis of the PACMAN and BREATHE data (OR: 0.93, 95% CI: 0.65-1.32; I2: 0.0%).

Conclusion: Children treated with antibiotic in the first three years of life are more likely to develop asthma, but there is no evidence that the exposure to antibiotic is associated with increase d risk of asthma exacerbations.

Item Type:	Article
Schools and Departments:	Brighton and Sussex Medical School > Clinical and Experimental Medicine
Depositing User:	Nicholas Christian Joseph Heavey
Date Deposited:	11 May 2017 08:34
Last Modified:	07 Aug 2019 10:15
URI:	http://sro.sussex.ac.uk/id/eprint/68051

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