Facial motor neuron migration advances

Wanner, Sarah J, Saeger, Ivan, Guthrie, Sarah and Prince, Victoria E (2013) Facial motor neuron migration advances. Current Opinion in Neurobiology, 23 (6). pp. 943-950. ISSN 0959-4388

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During development, the migration of specific neuronal subtypes is required for the correct establishment of neural circuits. In mice and zebrafish, facial branchiomotor (FBM) neurons undergo a tangential migration from rhombomere 4 caudally through the hindbrain. Recent advances in the field have capitalized on genetic studies in zebrafish and mouse, and high-resolution time-lapse imaging in zebrafish. Planar cell polarity signaling has emerged as a critical conserved factor in FBM neuron migration, functioning both within the neurons and their environment. In zebrafish, migration depends on specialized 'pioneer' neurons to lead follower FBM neurons through the hindbrain, and on interactions with structural components including pre-laid axon tracts and the basement membrane. Despite fundamental conservation, species-specific differences in migration mechanisms are being uncovered.

Item Type: Article
Schools and Departments: School of Life Sciences > Neuroscience
Depositing User: Ashleigh Cave
Date Deposited: 10 May 2017 08:03
Last Modified: 11 Nov 2019 13:03
URI: http://sro.sussex.ac.uk/id/eprint/68027
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