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Facial motor neuron migration advances
journal contribution
posted on 2023-06-09, 06:13 authored by Sarah J Wanner, Ivan Saeger, Sarah GuthrieSarah Guthrie, Victoria E PrinceDuring development, the migration of specific neuronal subtypes is required for the correct establishment of neural circuits. In mice and zebrafish, facial branchiomotor (FBM) neurons undergo a tangential migration from rhombomere 4 caudally through the hindbrain. Recent advances in the field have capitalized on genetic studies in zebrafish and mouse, and high-resolution time-lapse imaging in zebrafish. Planar cell polarity signaling has emerged as a critical conserved factor in FBM neuron migration, functioning both within the neurons and their environment. In zebrafish, migration depends on specialized 'pioneer' neurons to lead follower FBM neurons through the hindbrain, and on interactions with structural components including pre-laid axon tracts and the basement membrane. Despite fundamental conservation, species-specific differences in migration mechanisms are being uncovered.
History
Publication status
- Published
Journal
Current Opinion in NeurobiologyISSN
0959-4388Publisher
ElsevierExternal DOI
Issue
6Volume
23Page range
943-950Department affiliated with
- Neuroscience Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2017-05-10Usage metrics
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