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Indomethacin electrospun nanofibers for colonic drug delivery: in vitro dissolution studies
journal contribution
posted on 2023-06-09, 06:11 authored by Abbas Akhgari, Zohreh Heshmati, Hadi Afrasiabi Garekani, Fatemeh Sadeghi, Atena Sabbagh, Behzad Sharif Makhmalzadeh, Ali NokhodchiGenerally, although the conventional drug delivery systems, such as using only pHdependent polymers or time-dependent release systems are popular, the individuals’ variations of physiological conditions usually lead to premature or imperfect drug release from each of these systems. Therefore, a combination of pH- and time-dependent polymers could be more reliable for delivering drugs to the lower GI tract such as colon. To this end, electrospinning method was used as a fabrication approach for preparing electrospun nanofibers of indomethacin aimed for colon delivery. Formulations were prepared based on a 3 2 full factorial design. Independent variables were the drug:polymer ratio (with the levels of 3:5, 4.5:5 and 6:5 w/w) and Eudragit S:Eudragit RS w/w ratio (20:80, 60:40 and 100:0). The evaluated responses were drug release at pH 1.2, 6.4, 6.8 and 7.4. Combinations of Eudragit S (ES), Eudragit RS (ERS) and drug based on factorial design were loaded in 10 ml syringes. 3 Electrospinning method was used to prepare electrospun nanofibers from electrospinning solutions. Conductivity and the viscosity of the solutions were analyzed prior to electrospinning. After collection, the nanofibers were evaluated in terms of morphology and drug release. It was shown that the ratio of drug:polymer and polymer:polymer were pivotal factors to control the drug release from nanofibers. A formulation containing Eudragit S:Eudragit RS (60:40) and drug:polymer ratio of 3:5 exhibited the most appropriate drug release as a colon delivery system with a minor release at pH 1.2, 6.4 and 6.8 and major release at pH 7.4. Nanofibers resulted from this formulation were also more uniform and contained fewer amounts of beads. It was demonstrated that the electrospinning could be regarded as a modern approach for the preparation of colon drug delivery systems leading to marketable products.
History
Publication status
- Published
File Version
- Accepted version
Journal
Colloids and Surfaces B: BiointerfacesISSN
0927-7765Publisher
ElsevierExternal DOI
Volume
152Page range
29-35Department affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-05-08First Open Access (FOA) Date
2017-12-24First Compliant Deposit (FCD) Date
2017-05-08Usage metrics
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