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Relationship between serum anti-heat shock protein 27 antibody levels and obesity

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posted on 2023-06-09, 05:52 authored by Mehrdad Kargar, Samira Tavassoli, Amir Avan, Mahmoud Ebrahim, Mahmoud Reza Azarpazhooh, Rasool Asoodeh, Mohsen Nematy, Seyed Mahdi Hassanian, Farzad Rahmani, Elham Mohammadzade, Habibollah Esmaeili, Mohsen Moohebat, Gordon FernsGordon Ferns, Majid Ghayour-Mobarhan, Seyed Mohammed Reza Parizadeh
Background Heat shock protein 27 (HSP27) is an intracellular molecular chaperone that is expressed at high levels following the exposure of cells to environmental stressors such as heat, toxins, and free radicals. High levels of HSP antigens and antibody titers have been reported in several conditions including cardiovascular disease and cancers. We measured serum anti-HSP27 antibody levels in 993 subjects and assessed the associations between serum anti-HSP27 antibody levels and demographic characteristics including coronary risk factors. Methods A total of 993 subjects were recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorders (MASHAD) cohort study. Demographic, clinical, and biochemical parameters and serum anti-HSP27 antibody titers were determined in all the subjects. Results Serum anti-HSP27 antibody levels increased with increasing age in men. No significant differences in levels were detected between men and women. Serum anti-HSP27 antibody levels were significantly higher in obese subjects than in nonobese subjects (P = 0.046); however, no significant influence of smoking status was observed. Moreover, serum anti-HSP27 antibody titers were positively associated with age, body mass index, waist/hip ratio, the presence of diabetes mellitus, nonsmoking habit, serum triglycerides, cholesterol, and high-sensitivity c-reactive protein. Conclusion We have found that serum anti-HSP27 antibody titers are related to several cardiovascular risk factors, necessitating further studies on the value of this emerging marker for risk stratification.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Clinical Biochemistry

ISSN

0009-9120

Publisher

Elsevier

Issue

12

Volume

50

Page range

690-695

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-04-24

First Open Access (FOA) Date

2018-02-22

First Compliant Deposit (FCD) Date

2017-04-21

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