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cAMP responsive element-binding protein phosphorylation is necessary for perirhinal long-term potentiation and recognition memory

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posted on 2023-06-09, 05:39 authored by E Clea Warburton, Colin P J Glover, Peter V Massey, Huimin Wan, Ben Johnson, Alison Bienemann, Ule Deuschle, James N C Kew, John P Aggleton, Zafar I Bashir, James Uney, Malcolm W Brown
We established the importance of phosphorylation of cAMP responsive element-binding protein (CREB) to both the familiarity discrimination component of long-term recognition memory and plasticity within the perirhinal cortex of the temporal lobe. Adenoviral transduction of perirhinal cortex (and adjacent visual association cortex) with a dominant-negative inhibitor of CREB impaired the preferential exploration of novel over familiar objects at a long (24 h) but not a short (15 min) delay, disrupted the normal reduced activation of perirhinal neurons to familiar compared with novel pictures, and impaired long-term potentiation of synaptic transmission in perirhinal slices. The consistency of these effects across the behavioral, systems, and cellular levels of analysis provides strong evidence for involvement of CREB phosphorylation in synaptic plastic processes within perirhinal cortex necessary for long-term recognition memory.

History

Publication status

  • Published

File Version

  • Published version

Journal

Journal of Neuroscience

ISSN

0270-6474

Publisher

Society for Neuroscience

Issue

27

Volume

25

Page range

6296-6303

Department affiliated with

  • Neuroscience Publications

Research groups affiliated with

  • Sussex Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-04-07

First Open Access (FOA) Date

2017-04-07

First Compliant Deposit (FCD) Date

2017-04-06

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