hs-CRP is strongly associated with coronary heart disease (CHD): A data mining approach using decision tree algorithm

Tayefi, Maryam, Tajfard, Mohammad, Saffar, Sara, Hanachi, Parichehr, Amirabadizadeh, Ali Reza, Esmaeily, Habibollah, Taghipour, Ali, Ferns, Gordon A, Moohebati, Mohsen and Ghayour-Mobarhan, Majid (2017) hs-CRP is strongly associated with coronary heart disease (CHD): A data mining approach using decision tree algorithm. Computer Methods and Programs in Biomedicine, 141. pp. 105-109. ISSN 0169-2607

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BACKGROUND AND AIMS: Coronary heart disease (CHD) is an important public health problem globally. Algorithms incorporating the assessment of clinical biomarkers together with several established traditional risk factors can help clinicians to predict CHD and support clinical decision making with respect to interventions. Decision tree (DT) is a data mining model for extracting hidden knowledge from large databases. We aimed to establish a predictive model for coronary heart disease using a decision tree algorithm.

METHODS: Here we used a dataset of 2346 individuals including 1159 healthy participants and 1187 participant who had undergone coronary angiography (405 participants with negative angiography and 782 participants with positive angiography). We entered 10 variables of a total 12 variables into the DT algorithm (including age, sex, FBG, TG, hs-CRP, TC, HDL, LDL, SBP and DBP).

RESULTS: Our model could identify the associated risk factors of CHD with sensitivity, specificity, accuracy of 96%, 87%, 94% and respectively. Serum hs-CRP levels was at top of the tree in our model, following by FBG, gender and age.

CONCLUSION: Our model appears to be an accurate, specific and sensitive model for identifying the presence of CHD, but will require validation in prospective studies.

Item Type: Article
Keywords: Data mining Decision tree Coronary artery disease hs-CRP
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Subjects: R Medicine > RA Public aspects of medicine
Depositing User: Gordon Ferns
Date Deposited: 02 Apr 2017 08:57
Last Modified: 02 Jul 2019 16:06
URI: http://sro.sussex.ac.uk/id/eprint/67239

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