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Accepted version of UKCTOCS SAQ.pdf (1.01 MB)

The effect of ovarian cancer screening on sexual activity and functioning: results from the UK collaborative trial of ovarian cancer screening RCT

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posted on 2023-06-09, 05:33 authored by Lesley FallowfieldLesley Fallowfield, Ivonne Solis-Trapala, Usha Menon, Carolyn Langridge, Shirley May, Ian Jacobs, Valerie JenkinsValerie Jenkins
Background: To examine the impact of multimodal (MMS) and ultrasound (USS) screening on the sexual activity and functioning of 22,966 women in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) RCT. Methods: Fallowfield’s Sexual Activity Questionnaire (FSAQ) was completed prior to randomisation, then annually in a random sample (RS) of women from MMS, USS and control groups. Any women in the study who required repeat screening due to unsatisfactory results formed an Events Sample (ES); they completed questionnaires following an event and annually thereafter. Results: Over time in the RS (n=1,339) there was no difference between the MMS and USS groups in sexual activity compared with controls. In the ES there were significant differences between the USS group (n=10,156) and the MMS group (n=12,810). The USS group had lower pleasure scores (mean difference = -0.14, P=0.046). For both groups women who had =2 repeat screens, showed a decrease in mean pleasure scores compared to their annual scores (mean difference = -0.16, P=0.005). Similarly mean pleasure scores decreased following more intensive screens compared to annual screening (mean difference= -0.09, P=0.046). Conclusion: Ovarian cancer screening did not affect sexual activity and functioning unless a woman had abnormal results and underwent repeated or higher level screening.

Funding

United Kingdom Collaborative Trial of Ovarian Cancer Screening; G0543; MRC-MEDICAL RESEARCH COUNCIL; 09/800/33

History

Publication status

  • Published

File Version

  • Accepted version

Journal

British Journal of Cancer

ISSN

0007-0920

Publisher

Nature Publishing Group

Issue

8

Volume

116

Page range

1111-1117

Department affiliated with

  • Sussex Health Outcomes Research & Education in Cancer (SHORE-C) Publications

Research groups affiliated with

  • Sussex Health Outcomes Research and Education in Cancer Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-03-28

First Open Access (FOA) Date

2017-09-21

First Compliant Deposit (FCD) Date

2017-03-27

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