Accepted version of UKCTOCS SAQ.pdf (1.01 MB)
The effect of ovarian cancer screening on sexual activity and functioning: results from the UK collaborative trial of ovarian cancer screening RCT
journal contribution
posted on 2023-06-09, 05:33 authored by Lesley FallowfieldLesley Fallowfield, Ivonne Solis-Trapala, Usha Menon, Carolyn Langridge, Shirley May, Ian Jacobs, Valerie JenkinsValerie JenkinsBackground: To examine the impact of multimodal (MMS) and ultrasound (USS) screening on the sexual activity and functioning of 22,966 women in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) RCT. Methods: Fallowfield’s Sexual Activity Questionnaire (FSAQ) was completed prior to randomisation, then annually in a random sample (RS) of women from MMS, USS and control groups. Any women in the study who required repeat screening due to unsatisfactory results formed an Events Sample (ES); they completed questionnaires following an event and annually thereafter. Results: Over time in the RS (n=1,339) there was no difference between the MMS and USS groups in sexual activity compared with controls. In the ES there were significant differences between the USS group (n=10,156) and the MMS group (n=12,810). The USS group had lower pleasure scores (mean difference = -0.14, P=0.046). For both groups women who had =2 repeat screens, showed a decrease in mean pleasure scores compared to their annual scores (mean difference = -0.16, P=0.005). Similarly mean pleasure scores decreased following more intensive screens compared to annual screening (mean difference= -0.09, P=0.046). Conclusion: Ovarian cancer screening did not affect sexual activity and functioning unless a woman had abnormal results and underwent repeated or higher level screening.
Funding
United Kingdom Collaborative Trial of Ovarian Cancer Screening; G0543; MRC-MEDICAL RESEARCH COUNCIL; 09/800/33
History
Publication status
- Published
File Version
- Accepted version
Journal
British Journal of CancerISSN
0007-0920Publisher
Nature Publishing GroupExternal DOI
Issue
8Volume
116Page range
1111-1117Department affiliated with
- Sussex Health Outcomes Research & Education in Cancer (SHORE-C) Publications
Research groups affiliated with
- Sussex Health Outcomes Research and Education in Cancer Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-03-28First Open Access (FOA) Date
2017-09-21First Compliant Deposit (FCD) Date
2017-03-27Usage metrics
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