Trends - Accepted version.pdf (2.06 MB)
Direct effects of anti-angiogenic therapies on tumor cells: VEGF signaling
journal contribution
posted on 2023-06-09, 05:05 authored by Thomas Simon, Teresa Gagliano, Georgios GiamasGeorgios GiamasOver recent decades anti-angiogenic therapies (AATs) have produced promising results in the treatment of different malignancies. Unfortunately, resistance often develops and patients ultimately relapse. In an attempt to elucidate the causes of recurrence, most studies have focused on tumor responses to hypoxic conditions induced by AAT. However, strategies targeting these mechanisms of resistance are still failing to improve treatments. Furthermore, a potential direct impact of AAT on tumor cells cannot be overlooked. This review provides a novel overview of the different aspects of the tumor cell response to AAT. Conflicting data regarding the nature of this effect are discussed and reconciled, thus providing new insight into the discussion of tumor recurrence despite AAT.
History
Publication status
- Published
File Version
- Accepted version
Journal
Trends in Molecular MedicineISSN
1471-4914Publisher
ElsevierExternal DOI
Issue
3Volume
23Page range
282-292Department affiliated with
- Biochemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-02-08First Open Access (FOA) Date
2018-02-04First Compliant Deposit (FCD) Date
2017-02-08Usage metrics
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