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A Randomised Controlled Trial of Efficacy of Cognitive Rehabilitation in Multiple Sclerosis- A Cognitive, Behavioural, and MRI Study.pdf (1.44 MB)

A randomised controlled trial of efficacy of cognitive rehabilitation in multiple sclerosis: a cognitive, behavioural, and MRI study

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posted on 2023-06-09, 04:59 authored by J Campbell, D Langdon, Mara Cercignani, W Rashid
Aim: To explore the efficacy of home-based, computerised, cognitive rehabilitation in patients with multiple sclerosis using neuropsychological assessment and advanced structural and functional magnetic resonance imaging (fMRI). Methods: 38 patients with MS and cognitive impairment on the Brief International Cognitive Assessment for MS (BICAMS) were enrolled. Patients were randomised to undergo 45 minutes of computerised cognitive rehabilitation using RehaCom software (n = 19) three times weekly for six weeks or to a control condition (n = 19). Neuropsychological and MRI data were obtained at baseline (time 1), following the 6-week intervention (time 2), and after a further twelve weeks (time 3). Cortical activations were explored using fMRI and microstructural changes were explored using quantitative magnetisation transfer (QMT) imaging. Results: The treatment group showed a greater improvement in SDMT gain scores between baseline and time 2 compared to the control group (p = 0.005). The treatment group exhibited increased activation in the bilateral prefrontal cortex and right temporoparietal regions relative to control group at time 3 (p < 0.05FWE??corrected). No significant changes were observed on QMT. Conclusion: This study supports the hypothesis that home-based, computerised, cognitive rehabilitation may be effective in improving cognitive performance in patients with MS. Clinical trials registration is ISRCTN54901925.

History

Publication status

  • Published

File Version

  • Published version

Journal

Journal of Neural Transplantation and Plasticity

ISSN

0792-8483

Publisher

Hindawi Publishing Corporation

Volume

2016

Page range

4292585

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-01-30

First Open Access (FOA) Date

2017-01-30

First Compliant Deposit (FCD) Date

2017-01-30

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