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Cytomegalovirus as a driver of excess cardiovascular mortality in rheumatoid arthritis: a red herring or a smoking gun?

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posted on 2023-06-09, 04:47 authored by Alejandra Pera RojasAlejandra Pera Rojas, Iain Broadley, Kevin DaviesKevin Davies, Florian KernFlorian Kern
Rheumatoid arthritis (RA) is the most common inflammatory arthritis worldwide. Apart from its well known manifestations involving the joints (e.g. deformity, swelling, synovial inflammation), there are widespread, extra-articular manifestations that also involve the cardiovascular (CV) system. The consequences of CV involvement are often serious; cerebrovascular disease, ischemic heart disease and CV disease (CVD)-associated death are up to 50% higher in the context of RA leading to a reduction of life-expectancy in these patients of 3-10 years compared with the general population. To date, no satisfactory explanation of this phenomenon has been found, or maybe, it has been overlooked?

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Circulation Research

ISSN

0009-7330

Publisher

Lippincott, Williams & Wilkins

Issue

2

Volume

120

Page range

274-277

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-01-18

First Open Access (FOA) Date

2017-07-20

First Compliant Deposit (FCD) Date

2017-01-18

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