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Distinct memory engrams in the infralimbic cortex of rats control opposing environmental actions on a learned behavior

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Version 2 2023-06-12, 08:37
Version 1 2023-06-09, 04:44
journal contribution
posted on 2023-06-12, 08:37 authored by Nobuyoshi Suto, Amanda Laque, Genna L De Ness, Grant E Wagner, Debbie Watry, Tony Kerr, Eisuke KoyaEisuke Koya, Mark R Mayford, Bruce T Hope, Friedbert Weiss
Conflicting evidence exists regarding the role of infralimbic cortex (IL) in the environmental control of appetitive behavior. Inhibition of IL, irrespective of its intrinsic neural activity, attenuates not only the ability of environmental cues predictive of reward availability to promote reward seeking, but also the ability of environmental cues predictive of reward omission to suppress this behavior. Here we report that such bidirectional behavioral modulation in rats is mediated by functionally distinct units of neurons (neural ensembles) that are concurrently localized within the same IL brain area but selectively reactive to different environmental cues. Ensemble-specific neural activity is thought to function as a memory engram representing a learned association between environment and behavior. Our findings establish the causal evidence for the concurrent existence of two distinct engrams within a single brain site, each mediating opposing environmental actions on a learned behavior.

History

Publication status

  • Published

File Version

  • Published version

Journal

eLife

ISSN

2050-084X

Publisher

eLife Sciences Publications

Volume

5

Article number

e21920

Department affiliated with

  • Psychology Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-01-13

First Open Access (FOA) Date

2017-01-13

First Compliant Deposit (FCD) Date

2017-01-13

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