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Testing regimes in clinical trials: evidence from four polio vaccine trajectories

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journal contribution
posted on 2023-06-09, 04:21 authored by Ohid YaqubOhid Yaqub
This paper highlights distinctive features of a neglected class of economic activity in the domain of medical innovation, namely the creation of testing regimes in clinical trials, asking how their nature might be expected to affect innovation of medical technology. It argues firstly that clinical trials are not simply about passively validating an already well-known technology and verifying its safety. Rather, clinical trials are part of a more active process of learning that allows pharmaceutical innovations to be useful outside the laboratory. It argues secondly that product development can proceed along a number of long and costly paths before a product’s behaviour in actual practice becomes clear, which can make selecting between alternative courses of action difficult. Thus, product choice and product development need to go hand-in-hand. To consider these arguments, the paper maps out four trajectories of polio vaccine development, tracing their paths through clinical trials since the 1950s, and describes some of the defining features of testing regimes for medical innovation. These include institutions that integrate knowledge and co-ordinate skills in testing processes, and capabilities for allocating testing resources, managing testability constraints, sharing knowledge and improving commensurability between testing communities.

Funding

Serendipity in Science, Technology and Innovation; G1446; ESRC-ECONOMIC & SOCIAL RESEARCH COUNCIL; ES/L011409/1

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Research Policy

ISSN

0048-7333

Publisher

Elsevier

Issue

2

Volume

46

Page range

475-484

Department affiliated with

  • SPRU - Science Policy Research Unit Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-12-07

First Open Access (FOA) Date

2018-06-16

First Compliant Deposit (FCD) Date

2016-12-08

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