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AMPA receptor positive allosteric modulators: potential for the treatment of neuropsychiatric and neurological disorders

journal contribution
posted on 2023-06-09, 03:47 authored by Tristan Reuillon, Simon Ward, Paul Beswick
The neurotransmitter glutamate and its receptors have long been of interest to scientists involved in pharmaceutical research since dysfunction of the glutamatergic signalling pathway has been associated with the pathophysiology of several psychiatric and neurological disorders. The research on AMPAR positive allosteric modulators offers opportunities to modulate fast excitatory synaptic transmission and identify new potential therapeutic agents for a range of neurodiseases. The field of AMPAR modulators continues to be a dynamic area of drug discovery with a pronounced diversification of the chemotypes explored in recent years. This article reviews literature published in this area in the last 6 years, focusing on the new core templates, some derived from high-throughput screens, with an emphasis on structure-activity relationships, drug metabolism and pharmacokinetics properties, and pharmacological profiles of these series.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Current Topics in Medicinal Chemistry

ISSN

1568-0266

Publisher

Bentham Science Publishers

Issue

29

Volume

16

Page range

3536-3565

Department affiliated with

  • Chemistry Publications

Research groups affiliated with

  • Sussex Drug Discovery Centre Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2016-10-31

First Compliant Deposit (FCD) Date

2016-10-31

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