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Ghafourian, Taravat and Barzegar-Jalali, Mohammad (2002) Theoretical modeling of oral absorption of barbiturates. Farmaco, 57 (7). pp. 565-567. ISSN 0014-827X
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Official URL: https://doi.org/10.1016/S0014-827X(02)01249-1
Abstract
The structural characteristics governing gastric absorption of barbiturates were studied using QSAR methodology. The results showed that the gastric absorption rate constant could be modeled using the theoretical parameters, accessible surface area, atomic charges and electrostatic potentials. Using molecular connectivity indexes was also satisfactory in modeling the absorption.
Item Type: | Article |
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Keywords: | allobarbital; amobarbital; aprobarbital; barbital; barbituric acid derivative; butethal; cyclobarbital; ethallobarbital; hexobarbital; idobarbital; mephebarbital; methylphenobarbital; pentobarbital; phenobarbital; secbutabarbital; secobarbital; talbutal; unclassified drug; barbituric acid derivative, conference paper; drug absorption; electric potential; parameter; quantitative structure activity relation; stomach absorption; theoretical model; absorption; article; biological model; human; intestine absorption; metabolism; mouth mucosa, Absorption; Barbiturates; Human; Intestinal Absorption; Models, Biological; Mouth Mucosa; Quantitative Structure-Activity Relationship; Absorption; Humans; Intestinal Absorption; Quantitative Structure-Activity Relationship |
Schools and Departments: | School of Life Sciences > Biochemistry |
Depositing User: | Taravat Ghafourian |
Date Deposited: | 28 Nov 2017 13:51 |
Last Modified: | 02 Jul 2019 17:18 |
URI: | http://sro.sussex.ac.uk/id/eprint/64164 |
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