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Surfactants as penetration enhancers for dermal and transdermal drug delivery

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posted on 2023-06-09, 03:25 authored by Taravat Ghafourian, Ali Nokhodchi, W Kaialy
Owing to the specific molecular structure of surfactants, these compounds can penetrate into the stratum corneum (SC) and thereby increase the transdermal absorption of drugs. As a result, surfactants are some of the most widely used enhancers in transdermal drug delivery formulations/systems. Starting with an introduction into the chemical structure and physicochemical characteristics of surfactants, this chapter is focused on the application of various surfactants for increasing the skin absorption of drugs and the mechanisms involved in this process. In particular, application of various ionic and nonionic surfactants and synergism with physical and chemical permeation enhancement methods such as electrophoresis have been discussed, and key publications in this subject area have been introduced. © Springer-Verlag Berlin Heidelberg 2015.

History

Publication status

  • Published

Journal

Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the Stratum Corneum

Publisher

Springer Berlin Heidelberg

Page range

207-230

Book title

Percutaneous penetration enhancers chemical methods in penetration enhancement: Modification of the stratum corneum

ISBN

9783662470398

Department affiliated with

  • Biochemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Editors

H I Maibach, N Dragicevic

Legacy Posted Date

2017-12-01

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