Surfactants as penetration enhancers for dermal and transdermal drug delivery

Ghafourian, T, Nokhodchi, A and Kaialy, W (2015) Surfactants as penetration enhancers for dermal and transdermal drug delivery. In: Dragicevic, N and Maibach, H I (eds.) Percutaneous penetration enhancers chemical methods in penetration enhancement: Modification of the stratum corneum. Springer Berlin Heidelberg, pp. 207-230. ISBN 9783662470398

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Owing to the specific molecular structure of surfactants, these compounds can penetrate into the stratum corneum (SC) and thereby increase the transdermal absorption of drugs. As a result, surfactants are some of the most widely used enhancers in transdermal drug delivery formulations/systems. Starting with an introduction into the chemical structure and physicochemical characteristics of surfactants, this chapter is focused on the application of various surfactants for increasing the skin absorption of drugs and the mechanisms involved in this process. In particular, application of various ionic and nonionic surfactants and synergism with physical and chemical permeation enhancement methods such as electrophoresis have been discussed, and key publications in this subject area have been introduced. © Springer-Verlag Berlin Heidelberg 2015.

Item Type: Book Section
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: Taravat Ghafourian
Date Deposited: 01 Dec 2017 07:36
Last Modified: 01 Dec 2017 07:36
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