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Middleton et al 2016 Can interventions that aim to decrease LD hazard at non-domestic sites be effective without negatively affecting ecosystem health A systematic review protocol.pdf (994.51 kB)

Can interventions that aim to decrease Lyme disease hazard at non-domestic sites be effective without negatively affecting ecosystem health? A systematic review protocol

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journal contribution
posted on 2023-06-12, 08:32 authored by Jo MiddletonJo Middleton, I Cooper, A S Rott
Background Lyme disease (LD) is the most commonly reported, broadly distributed vector-borne disease of the northern temperate zone. It is transmitted by ticks and, if untreated, can cause skin, cardiac, nervous system and musculoskeletal disease. The distribution and incidence of LD is increasing across much of North America and Western Europe. Interventions to decrease exposure to LD hazard by encouraging behavioural change have low acceptance in high risk groups, and a safe, effective human LD vaccine is not presently available. As a result, habitat level interventions to decrease LD hazard itself (i.e. levels of infected ticks) have been proposed. However, some interventions may potentially negatively affect ecosystem health, and consequentially be neither desirable, nor politically feasible. This systematic review will catalogue interventions that aim to reduce LD hazard at non-domestic sites, and examine the evidence supporting those which are unlikely to negatively affect ecosystem health. Methods The review will be carried out in two steps. First, a screening and cataloguing stage will be conducted to identify and characterise interventions to decrease LD hazard at non-domestic sites. Secondly, the subset of interventions identified during cataloguing as unlikely to negatively affect ecosystem health will be investigated. In the screening and cataloguing step literature will be collected through database searching using pre-chosen search strings, hand-searching key journals and reviewing the websites of public health bodies. Further references will be identified by contacting stakeholders and researchers. Article screening and assessment of the likely effects of interventions on ecosystem health will be carried out independently by two reviewers. A third reviewer will be consulted if disagreements arise. The cataloguing step results will be presented in tables. Study quality will then be assessed independently by two reviewers, using adapted versions of established tools developed in healthcare research. These results will be presented in a narrative synthesis alongside tables. Though a full meta-analysis is not expected to be possible, if sub-groups of studies are sufficiently similar to compare, a partial meta-analysis will be carried out.

Funding

Ecological determinants of Lyme disease in the South Downs National Park and the potential for One Health based interventions; NINEVEH Charitable Trust

Ecological determinants of Lyme disease in the South Downs National Park and the potential for One Health based interventions; The British Deer Society; RES2015JM

History

Publication status

  • Published

File Version

  • Published version

Journal

Environmental Evidence

ISSN

2047-2382

Publisher

BioMed Central

Issue

23

Volume

5

Department affiliated with

  • Primary Care and Public Health Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-09-22

First Open Access (FOA) Date

2016-09-22

First Compliant Deposit (FCD) Date

2016-09-22

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