Abnormal whole-brain functional connection in amnestic mild cognitive impairment patients

Baia, Feng, Liaoc, Wei, Watson, David R, Shib, Yongmei, Wanga, Yi, Yuea, Chunxian, Tenga, Yuhuan, Wu, Di, Yonggui, Yuanb, Jianping, Jia and Zhijun, Zhanga (2011) Abnormal whole-brain functional connection in amnestic mild cognitive impairment patients. Behavioural Brain Research, 216 (2). 666 -672. ISSN 0166-4328

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Amnestic mild cognitive impairment (aMCI) patients are thought to be particularly vulnerable to convert
to clinical AD where functional disconnection is a major feature of the cortical neuropathology. However,
the presence and extent of whole-brain connectivity disturbances is largely unknown in aMCI patients.
Twenty-six aMCI patients and eighteen matched healthy subjects were evaluated at baseline and at mean
20 months follow up. Temporal correlations between spatially distinct regions were evaluated by using
longitudinal resting-state fMRI. Compared to normal aging controls, patterns of abnormal interregional
correlations in widely dispersed brain areas were identified in the patients, which also changed with
disease progression. These disturbances were found particularly in subcortical regions and frontal cortex.
Importantly, significantly decreased negative functional connection may be specifically associated with
the development of aMCI patients. This suggests a compensatory mechanism is underway where local
processing deficits are offset by recruitment of more dispersed cortical regions. In addition, the presence
of this increased connectivity is seen to eventually weaken with disease progression. The results suggest
that patterns of whole-brain functional connection may be a useful risk marker for conversion to AD in
aMCI patients.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
Depositing User: Parisa Rafizadeh-Farahani
Date Deposited: 03 Oct 2016 13:10
Last Modified: 02 Jul 2019 18:00
URI: http://sro.sussex.ac.uk/id/eprint/63515

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