Llewelyn, Martin and Cohen, Jonathan (2001) Superantigen antagonist peptides. Critical Care, 5. pp. 53-55. ISSN 1364-8535

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Abstract

The production of superantigenic exotoxins by Gram positive bacteria underlies the pathology of toxic shock syndrome. Future treatment strategies for superantigen-mediated diseases are likely to be directed at blocking the three-way interaction between superantigen, T cell receptor and major histocompatibility class II molecule, which inititates an excessive and disordered inflammatory response. In this article, we review the first published data to address one such strategy in the context of other recognised and experimental treatments.

Item Type:	Article
Schools and Departments:	Brighton and Sussex Medical School > Global Health and Infection
Depositing User:	Sandy Gray
Date Deposited:	03 Oct 2016 11:16
Last Modified:	02 Jul 2019 18:04
URI:	http://sro.sussex.ac.uk/id/eprint/63333

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