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Human leukocyte antigen class II haplotypes that protect against or predispose to streptococcal toxic shock

journal contribution
posted on 2023-06-09, 02:53 authored by Martin LlewelynMartin Llewelyn
In the United States, 1.5-5.2/100,000 persons develop invasive Streptococcus pyogenes infections each year, and approximately 10%-20% of these patients go on to develop streptococcal toxic shock syndrome (STSS). Patients who develop STSS usually present with generalized erythema, conjunctivitis, and confusion. Fulminant cardiovascular shock develops over a period of a few hours, accompanied by multiorgan failure. Between 20% and 40% of patients with STSS die, compared with approximately 10% of patients with invasive streptococcal disease without STSS.

History

Publication status

  • Published

Journal

Clinical Infectious Diseases

ISSN

1537-6591

Publisher

Oxford University Press

Issue

Sup 7

Volume

41

Page range

S445-S448

Department affiliated with

  • Global Health and Infection Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2016-09-14

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