Absent gender differences of hippocampal atrophy in amnestic type mild cognitive impairment

Bai, Feng, Zhanga, Zhijun, Watson, David R, Yu, Hui, Shi, Yongmei, Zhud, Wanlin, Wang, Liang, Yuan, Yonggui and Qian, Yun (2009) Absent gender differences of hippocampal atrophy in amnestic type mild cognitive impairment. Neuroscience Letters, 450 (2). pp. 85-89. ISSN 0304-3940

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Hippocampus displayed progressively gender-associated damage in Alzheimer’s disease. However, gender effects have been largely neglected in studies of amnestic type mild cognitive impairment (aMCI)patients who were believed to represent an early stage of this disease. The goal of this study was to use in vivo neuroimaging techniques to determine whether there were any evidences of gender differences in hippocampal atrophy in aMCI. A region of interest-based magnetic resonance imaging approach was
used to compare hippocampal volume between aMCI patients (22 male, 17 female) and normal aging controls (12 male, 11 female). Independent of group, male hippocampal volumes were larger than female volumes and right hippocampal volumeswere typically smaller than left volumes. Hippocampal volumes were significantly reduced in the clinical group but no gender differenceswere noted in terms of degree of atrophy present. However, female patients showed more impaired cognitive function than male patients
despite this apparent equivalence in atrophy. The absence of a gender difference suggested that early neuropathological progression might be independent of gender. However, the data also suggested female
aMCI patients had an increased vulnerability to cognitive impairment earlier in the illness course.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
Depositing User: Parisa Rafizadeh-Farahani
Date Deposited: 16 Aug 2016 05:58
Last Modified: 02 Jul 2019 18:00
URI: http://sro.sussex.ac.uk/id/eprint/62400

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