File(s) under permanent embargo
Abnormal white matter independent of hippocampal atrophy in amnestic type mild cognitive impairment
journal contribution
posted on 2023-06-09, 02:30 authored by Feng Bai, Zhijun Zhang, David R Watson, Hui Yu, Yongmei Shi, Yonggui YuanaHippocampal atrophy is the key marker in the pathogenesis of Alzheimer's disease (AD), which is associated with white matter (WM) disruption. This type of WM disruption could partly explain AD-related pathology. However, relatively little attention has been directed toward WM disruption which may be independent of these fundamental gray matter (GM) changes in amnestic mild cognitive impairment (aMCI) which is associated with high risk of AD. To evaluate the differences of WM integrity between aMCI patients (N = 32) and healthy controls (N = 31), whole-brain voxel-based methods were applied to diffusion tensor imaging. To explore the possible independence of WM changes from GM loss, an index of hippocampal atrophy was used to partial out GM effects. aMCI patients showed WM disruption in frontal lobe, temporal lobe, internal capsule, cingulate gyrus and precuneus. The findings supported the evidence of independent patterns of degeneration in WM tracts which may co-act in the WM pathological process of aMCI patients. As aMCI is a putatively prodromal syndrome to AD, these data may assist with a better understanding of WM pathological change associated with the development of AD.
History
Publication status
- Published
File Version
- Published version
Journal
Neuroscience LettersISSN
0304-3940Publisher
ElsevierExternal DOI
Issue
2Volume
462Page range
147-151Department affiliated with
- BSMS Neuroscience Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2016-08-10First Compliant Deposit (FCD) Date
2016-08-10Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC