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Abnormal white matter independent of hippocampal atrophy in amnestic type mild cognitive impairment

journal contribution
posted on 2023-06-09, 02:30 authored by Feng Bai, Zhijun Zhang, David R Watson, Hui Yu, Yongmei Shi, Yonggui Yuana
Hippocampal atrophy is the key marker in the pathogenesis of Alzheimer's disease (AD), which is associated with white matter (WM) disruption. This type of WM disruption could partly explain AD-related pathology. However, relatively little attention has been directed toward WM disruption which may be independent of these fundamental gray matter (GM) changes in amnestic mild cognitive impairment (aMCI) which is associated with high risk of AD. To evaluate the differences of WM integrity between aMCI patients (N = 32) and healthy controls (N = 31), whole-brain voxel-based methods were applied to diffusion tensor imaging. To explore the possible independence of WM changes from GM loss, an index of hippocampal atrophy was used to partial out GM effects. aMCI patients showed WM disruption in frontal lobe, temporal lobe, internal capsule, cingulate gyrus and precuneus. The findings supported the evidence of independent patterns of degeneration in WM tracts which may co-act in the WM pathological process of aMCI patients. As aMCI is a putatively prodromal syndrome to AD, these data may assist with a better understanding of WM pathological change associated with the development of AD.

History

Publication status

  • Published

File Version

  • Published version

Journal

Neuroscience Letters

ISSN

0304-3940

Publisher

Elsevier

Issue

2

Volume

462

Page range

147-151

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2016-08-10

First Compliant Deposit (FCD) Date

2016-08-10

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