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Bai et al. - 2011 - Specifically progressive deficits of brain functional marker in amnestic type mild cognitive impairment-annotated.pdf (407.99 kB)

Specifically progressive deficits of brain functional marker in amnestic type mild cognitive impairment

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posted on 2023-06-09, 02:30 authored by Feng Bai, David R Watson, Yongmei Shi, Yi Wang, Chunxian Yue, Yuhuan Teng, Di Wu, Yonggui Yuan, Zhijun Zhang
Background: Deficits of the default mode network (DMN) have been demonstrated in subjects with amnestic type mild cognitive impairment (aMCI) who have a high risk of developing Alzheimer’s disease (AD). However, no longitudinal study of this network has been reported in aMCI. Identifying links between development of DMN and aMCI progression would be of considerable value in understanding brain changes underpinning aMCI and determining risk of conversion to AD. Methodology/Principal Findings: Resting-state fMRI was acquired in aMCI subjects (n = 26) and controls (n = 18) at baseline and after approximately 20 months follow up. Independent component analysis was used to isolate the DMN in each participant. Differences in DMN between aMCI and controls were examined at baseline, and subsequent changes between baseline and follow-up were also assessed in the groups. Posterior cingulate cortex/precuneus (PCC/PCu) hyper-functional connectivity was observed at baseline in aMCI subjects, while a substantial decrement of these connections was evident at follow-up in aMCI subjects, compared to matched controls. Specifically, PCC/PCu dysfunction was positively related to the impairments of episodic memory from baseline to follow up in aMCI group. Conclusions/Significance: The patterns of longitudinal deficits of DMN may assist investigators to identify and monitor the development of aMCI.

History

Publication status

  • Published

File Version

  • Published version

Journal

PLoS ONE

ISSN

1932-6203

Publisher

Public Library of Science

Issue

9

Volume

6

Article number

e24271-e24271

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-08-10

First Open Access (FOA) Date

2016-08-10

First Compliant Deposit (FCD) Date

2016-08-10

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