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Gray matter concentration and effective connectivity changes in Alzheimer’s disease: a longitudinal structural MRI study

journal contribution
posted on 2023-06-09, 02:30 authored by Xingfeng Li, Damien Coyle, Liam Maguire, David R Watson, Thomas M McGinnity
Introduction Understanding disease progression in Alzheimer’s disease (AD) awaits the resolution of three fundamental questions: first, can we identify the location of “seed” regions where neuropathology is first present? Some studies have suggested the medial temporal lobe while others have suggested the hippocampus. Second, are there similar atrophy rates within affected regions in AD? Third, is there evidence of causality relationships between different affected regions in AD progression? Methods To address these questions, we conducted a longitudinalMRI study to investigate the gray matter (GM) changes in AD progression. Abnormal brain regions were localized by a standard voxel-based morphometry method, and the absolute atrophy rate in these regions was calculated using a robust regression method. Primary foci of atrophy were identified in the hippocampus and middle temporal gyrus (MTG). A model based upon the Granger causality approach was developed to investigate the cause–effect relationship over time between these regions based on GM concentration. Results Results show that in the earlier stages of AD, primary pathological foci are in the hippocampus and entorhinal cortex. Subsequently, atrophy appears to subsume the MTG. Conclusion The causality results show that there is in fact little difference between AD and age-matched healthy control in terms of hippocampus atrophy, but there are larger differences in MTG, suggesting that local pathology in MTG is the predominant progressive abnormality during intermediate stages of AD development.

History

Publication status

  • Published

File Version

  • Published version

Journal

Neuroradiology

ISSN

0028-3940

Publisher

Springer Verlag

Issue

10

Volume

53

Page range

733-748

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2016-08-10

First Compliant Deposit (FCD) Date

2016-08-10

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