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Normal levels of prepulse inhibition in the euthymic phase of bipolar disorder
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posted on 2023-06-09, 02:22 authored by Suzanne Lucia Barrett, Christopher Kelly, David Robert Watson, Robert Bell, David John KingBackground: Deficits in prepulse inhibition (PPI) of the acoustic startle response have been suggested as a potentially useful endophenotype for schizophrenia spectrum disorders and may explain certain symptoms and cognitive deficits observed in the psychoses. PPI deficits have also been found in mania, but it remains to be confirmed whether this dysfunction is present in the euthymic phase of bipolar disorder. Methods: Twenty-three adult patients with DSM-IV bipolar disorder were compared to 20 controls on tests of acoustic startle reactivity and PPI of the startle response. Sociodemographic and treatment variables were recorded and symptom scores assessed using the Hamilton Depression Inventory and the Young Mania Rating Scale. Results: Overall, the patient and control groups demonstrated similar levels of startle reactivity and PPI, although there was a trend for the inter-stimulus interval to differentially affect levels of PPI in the two groups. Conclusions: In contrast to bipolar patients experiencing a manic episode, general levels of PPI were normal in this euthymic sample. Further studies are required to confirm this finding and to determine the mechanisms by which this potential disruption/normalization occurs. It is suggested that an examination of PPI in a high-risk group is required to fully discount dysfunctional PPI as a potentially useful endophenotype for bipolar disorder.
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Publication status
- Published
File Version
- Published version
Journal
Psychological MedicineISSN
0033-2917Publisher
Cambridge University PressExternal DOI
Issue
12Volume
35Page range
1737-1746Department affiliated with
- BSMS Neuroscience Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2016-08-09First Compliant Deposit (FCD) Date
2016-08-09Usage metrics
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