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What is a pericyte?
journal contribution
posted on 2023-06-09, 02:15 authored by David Attwell, Anusha Mishra, Catherine HallCatherine Hall, Fergus M O’Farrell, Turgay DalkaraPericytes, spatially isolated contractile cells on capillaries, have been reported to control cerebral blood flow physiologically, and to limit blood flow after ischaemia by constricting capillaries and then dying. Paradoxically, a recent paper dismisses the idea of pericytes controlling cerebral blood flow, despite confirming earlier data showing a role for pericytes. We show that these discrepancies are apparent rather than real, and depend on the new paper defining pericytes differently from previous reports. An objective definition of different sub-classes of pericyte along the capillary bed is needed to develop novel therapeutic approaches for stroke and disorders caused by pericyte malfunction.
History
Publication status
- Published
File Version
- Published version
Journal
Journal of Cerebral Blood Flow and MetabolismISSN
0271-678XPublisher
Nature Publishing GroupExternal DOI
Issue
2Volume
36Page range
0271678X15610340Department affiliated with
- Psychology Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2016-07-26First Compliant Deposit (FCD) Date
2016-07-26Usage metrics
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