University of Sussex
Browse

File(s) under permanent embargo

What is a pericyte?

journal contribution
posted on 2023-06-09, 02:15 authored by David Attwell, Anusha Mishra, Catherine HallCatherine Hall, Fergus M O’Farrell, Turgay Dalkara
Pericytes, spatially isolated contractile cells on capillaries, have been reported to control cerebral blood flow physiologically, and to limit blood flow after ischaemia by constricting capillaries and then dying. Paradoxically, a recent paper dismisses the idea of pericytes controlling cerebral blood flow, despite confirming earlier data showing a role for pericytes. We show that these discrepancies are apparent rather than real, and depend on the new paper defining pericytes differently from previous reports. An objective definition of different sub-classes of pericyte along the capillary bed is needed to develop novel therapeutic approaches for stroke and disorders caused by pericyte malfunction.

History

Publication status

  • Published

File Version

  • Published version

Journal

Journal of Cerebral Blood Flow and Metabolism

ISSN

0271-678X

Publisher

Nature Publishing Group

Issue

2

Volume

36

Page range

0271678X15610340

Department affiliated with

  • Psychology Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2016-07-26

First Compliant Deposit (FCD) Date

2016-07-26

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC