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Circulating plasma microRNAs can differentiate human sepsis and Systemic Inflammatory Response Syndrome (SIRS).

journal contribution
posted on 2023-06-09, 01:56 authored by Stefano Caserta, Florian KernFlorian Kern, Jonathan Cohen, Stephen Drage, Sarah NewburySarah Newbury, Martin LlewelynMartin Llewelyn
Systemic inflammation in humans may be triggered by infection, termed sepsis, or non-infective processes, termed non-infective systemic inflammatory response syndrome (SIRS). MicroRNAs regulate cellular processes including inflammation and may be detected in blood. We aimed to establish definitive proof-of-principle that circulating microRNAs are differentially affected during sepsis and non-infective SIRS. Critically ill patients with severe (n?=?21) or non-severe (n?=?8) intra-abdominal sepsis; severe (n?=?23) or non-severe (n?=?21) non-infective SIRS; or no SIRS (n?=?16) were studied. Next-generation sequencing and qRT-PCR were used to measure plasma microRNAs. Detectable blood miRNAs (n?=?116) were generally up-regulated in SIRS compared to no-SIRS patients. Levels of these 'circulating inflammation-related microRNAs' (CIR-miRNAs) were 2.64 (IQR: 2.10-3.29) and 1.52 (IQR: 1.15-1.92) fold higher for non-infective SIRS and sepsis respectively (p?

History

Publication status

  • Published

File Version

  • Published version

Journal

Scientific Reports

ISSN

2045-2322

Publisher

Nature Publishing Group

Issue

1

Volume

6

Article number

a28006

Department affiliated with

  • BSMS Publications

Notes

Supplementary data available at http://www.nature.com/articles/srep28006

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-06-28

First Open Access (FOA) Date

2016-06-29

First Compliant Deposit (FCD) Date

2016-06-29

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