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Phosphine-free chiral iridium catalysts for asymmetric catalytic hydrogenation of simple ketones

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journal contribution
posted on 2023-06-12, 06:40 authored by Prashant Kumar, Torsten Irrgang, George KostakisGeorge Kostakis, Rhett Kempe
Novel pyridylalkylamine and aminopyridinato ligand stabilized iridium complexes with no P ligand are introduced. These complexes have been investigated as catalysts for asymmetric hydrogenation of simple ketones, resulting in an active catalyst for bulky alkyl aryl ketones that is a-methylpropiophenone. The ligands were synthesized from inexpensive starting materials and their modular design allows for the introduction of a broad variety of substitution patterns. Additionally, better activity and selectivity was observed at 20 °C and 20 bar H2 pressure with a catalyst loading as low as 0.05 mol% iridium. These phosphorus free catalysts have always been a central issue in both academic and industrial research.

History

Publication status

  • Published

File Version

  • Published version

Journal

RSC Advances

ISSN

2046-2069

Publisher

Royal Society of Chemistry

Issue

45

Volume

6

Page range

39335-39342

Department affiliated with

  • Chemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-06-15

First Open Access (FOA) Date

2016-06-29

First Compliant Deposit (FCD) Date

2016-06-29

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