c6ra04524c.pdf (711.39 kB)
Phosphine-free chiral iridium catalysts for asymmetric catalytic hydrogenation of simple ketones
Version 2 2023-06-12, 06:40
Version 1 2023-06-09, 01:41
journal contribution
posted on 2023-06-12, 06:40 authored by Prashant Kumar, Torsten Irrgang, George KostakisGeorge Kostakis, Rhett KempeNovel pyridylalkylamine and aminopyridinato ligand stabilized iridium complexes with no P ligand are introduced. These complexes have been investigated as catalysts for asymmetric hydrogenation of simple ketones, resulting in an active catalyst for bulky alkyl aryl ketones that is a-methylpropiophenone. The ligands were synthesized from inexpensive starting materials and their modular design allows for the introduction of a broad variety of substitution patterns. Additionally, better activity and selectivity was observed at 20 °C and 20 bar H2 pressure with a catalyst loading as low as 0.05 mol% iridium. These phosphorus free catalysts have always been a central issue in both academic and industrial research.
History
Publication status
- Published
File Version
- Published version
Journal
RSC AdvancesISSN
2046-2069Publisher
Royal Society of ChemistryExternal DOI
Issue
45Volume
6Page range
39335-39342Department affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2016-06-15First Open Access (FOA) Date
2016-06-29First Compliant Deposit (FCD) Date
2016-06-29Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC