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Proteome-wide dataset supporting functional study of tyrosine kinases in breast cancer

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posted on 2023-06-09, 01:17 authored by Nicos Angelopoulos, Justin Stebbing, Yichen Xu, Georgios GiamasGeorgios Giamas, Hua Zhang
Tyrosine kinases (TKs) play an essential role in regulating various cellular activities and dysregulation of TK signaling contributes to oncogenesis. However, less than half of the TKs have been thoroughly studied. Through a combined use of RNAi and stable isotope labeling with amino acids in cell culture (SILAC)-based quantitative proteomics, a global functional proteomic landscape of TKs in breast cancer was recently revealed highlighting a comprehensive and highly integrated signaling network regulated by TKs (Stebbing et al., 2015) [1]. We collate the enormous amount of the proteomic data in an open access platform, providing a valuable resource for studying the function of TKs in cancer and benefiting the science community. Here we present a detailed description related to this study (Stebbing et al., 2015) [1] and the raw data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the identifier PXD002065.

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Publication status

  • Published

File Version

  • Published version

Journal

Data in Brief

ISSN

2352-3409

Publisher

Elsevier

Volume

7

Page range

740-746

Department affiliated with

  • Biochemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-05-18

First Open Access (FOA) Date

2016-05-18

First Compliant Deposit (FCD) Date

2016-05-18

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